Dr. Mark Swain has been a practicing hepatologist and clinician-scientist since his arrival in Alberta in 1993. He holds numerous leadership roles in the Faculty of Medicine including (i) the Cal Wenzel Family Foundation Chair in Hepatology (a research chair), (ii) Head, Translational Research Core, Snyder Institute of Chronic Diseases, University of Calgary, (iii) Head, Division of Gastroenterology and Hepatology, University of Calgary. He has published widely in the areas of liver disease and autoimmunity, publishing more than 110 peer-reviewed articles to date. He has been invited extensively to speak at local, National and International medical and research conferences. He has served on a number of Editorial Boards (ie. Gut, American Journal of Physiology, Clinical Sciences) and has been frequently invited as a participant on a number of peer review committees at CIHR.
Dr. Swain has an active CIHR funded basic science focused research laboratory and his overall research program is concerned with two main themes: i) Mechanisms underlying the development of fatigue in liver disease, and ii) the innate immune response in the regulation of liver injury and inflammation.. Current research topics in which he is involved include: i) Innate immunity and novel regulatory immune pathways in liver inflammation, (ii) NKT cells in the liver, (iii) Brain-liver interactions, (iv) Development and regulation of sickness behaviors (including fatigue) in chronic inflammation.